DSM-IV defined conduct disorder and oppositional defiant disorder: an investigation of shared liability in female twins.
Psychol Med
; 44(5): 1053-64, 2014 Apr.
Article
em En
| MEDLINE
| ID: mdl-23795654
ABSTRACT
BACKGROUND:
DSM-IV specifies a hierarchal diagnostic structure such that an oppositional defiant disorder (ODD) diagnosis is applied only if criteria are not met for conduct disorder (CD). Genetic studies of ODD and CD support a combination of shared genetic and environmental influences but largely ignore the imposed diagnostic structure.METHOD:
We examined whether ODD and CD share an underlying etiology while accounting for DSM-IV diagnostic specifications. Data from 1446 female twin pairs, aged 11-19 years, were fitted to two-stage models adhering to the DSM-IV diagnostic hierarchy.RESULTS:
The models suggested that DSM-IV ODD-CD covariation is attributed largely to shared genetic influences.CONCLUSIONS:
This is the first study, to our knowledge, to examine genetic and environmental overlap among these disorders while maintaining a DSM-IV hierarchical structure. The findings reflect primarily shared genetic influences and specific (i.e. uncorrelated) shared/familial environmental effects on these DSM-IV-defined behaviors. These results have implications for how best to define CD and ODD for future genetically informed analyses.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtornos de Deficit da Atenção e do Comportamento Disruptivo
/
Transtorno da Conduta
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Doenças em Gêmeos
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Limite:
Adolescent
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Adult
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Child
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Female
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Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article