Structure-activity-relationship studies on dihydrofuran-fused perhydrophenanthrenes as an anti-Alzheimer's disease agent.
Bioorg Med Chem
; 21(15): 4459-71, 2013 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-23806833
As an extended study on development of anti-Alzheimer's disease agent, we newly synthesized various dihydrofuran-fused perhydrophenanthrenes via o-quinodimethane chemistry. This study revealed that the introduction of carbon side-chain on 8-position or removal of the acetal moiety on 3-position arose a cytotoxicity on rat cortical neurons. On the other hand, the ethereal or thio-ethereal substituent on 8-position enhanced the elongation effect on Aß-damaged neurons. The necessity of the cyano group on 10b position was also proved in this structure-activity-relationship study.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenantrenos
/
Doença de Alzheimer
/
Furanos
Limite:
Animals
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article