Unexpected distribution of cKIT and BRAF mutations among southern Italian patients with sinonasal melanoma.
Dermatology
; 226(3): 279-84, 2013.
Article
em En
| MEDLINE
| ID: mdl-23817129
ABSTRACT
BACKGROUND:
Racial and geographic factors seem to affect the incidence of cutaneous and mucosal melanoma.OBJECTIVE:
To investigate the occurrence of BRAF and cKIT impairments in patients with sinonasal melanoma in Southern Italy.METHODS:
Eleven sinonasal melanomas were screened for BRAF mutations and cKIT alterations by immunohistochemistry (CD117), fluorescence in situ hybridization and sequencing analyses.RESULTS:
A high prevalence (4/11; 36%) of BRAF mutations and lack of cKIT mutations were observed. Amplification of cKIT was found in 18% of cases; cKIT expression was detectable in 18% non-overlapping cases. No correlation between CD117 and cKIT alterations was observed. One (6%) cKIT and two (12%) BRAF mutations were detected in an additional series of 17 acral/mucosal melanomas from the same geographic areas.CONCLUSION:
Mutations of cKIT are infrequent in sinonasal melanoma in Southern Italy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
/
Neoplasias do Seio Maxilar
/
Proteínas Proto-Oncogênicas c-kit
/
Proteínas Proto-Oncogênicas B-raf
/
Melanoma
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article