Tfh and plasma cells are correlated with hypergammaglobulinaemia in patients with autoimmune hepatitis.
Liver Int
; 34(3): 405-15, 2014 Mar.
Article
em En
| MEDLINE
| ID: mdl-23826746
ABSTRACT
BACKGROUND:
This study aimed at examining the numbers of different subsets of circulating Tfh and B cells in patients with new onset autoimmune hepatitis (AIH).METHODS:
A total of 17 patients with new onset AIH and 17 age-/gender-matched healthy controls (HC) were examined for the numbers of ICOS(+) , PD-1(+) and IL-21(+) Tfh cells, CD27(+) , CD38(+) , CD95(+) , CD86(+) and IL-10(+) B cells were quantified by flow cytometry. The concentrations of serum IL-21 and IL-10 were examined.RESULTS:
In comparison with that in the HC, significantly increased numbers of circulating CD38(+) , CD86(+) or CD95(+) B cells, ICOS(+) and PD-1(+) Tfh cells and increased levels of serum IL-21, but reduced numbers of CD27(+) , IL-10(+) B cells were detected in the patients. The concentrations of serum IL-21 and IL-10 were positively correlated with the numbers of CD4(+) CXCR5(+) TFH and CD19(+) CD5(+) CD1d(+) B cells respectively. The numbers of ICOS(+) or PD-1(+) Tfh cells were correlated positively with CD86(+) or CD95(+) B cells in those patients respectively. The numbers of CD38(+) B cells, ICOS(+) or PD-1(+) Tfh cells were correlated positively with the concentrations of serum IgG or IgM in the patients respectively; the concentrations of serum IL-21 were correlated positively with serum IgG, IgA and IgM and the concentrations of serum IL-10 were correlated negatively with serum IgG and IgM in the patients.CONCLUSION:
Circulating activated Tfh and plasma cells may be associated with hypergammaglobulinaemia during the pathogenic process of AIH in humans.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plasmócitos
/
Subpopulações de Linfócitos T
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Hepatite Autoimune
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Hipergamaglobulinemia
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article