The detection of novelty relies on dopaminergic signaling: evidence from apomorphine's impact on the novelty N2.
PLoS One
; 8(6): e66469, 2013.
Article
em En
| MEDLINE
| ID: mdl-23840482
ABSTRACT
Despite much research, it remains unclear if dopamine is directly involved in novelty detection or plays a role in orchestrating the subsequent cognitive response. This ambiguity stems in part from a reliance on experimental designs where novelty is manipulated and dopaminergic activity is subsequently observed. Here we adopt the alternative approach:
we manipulate dopamine activity using apomorphine (D1/D2 agonist) and measure the change in neurological indices of novelty processing. In separate drug and placebo sessions, participants completed a von Restorff task. Apomorphine speeded and potentiated the novelty-elicited N2, an Event-Related Potential (ERP) component thought to index early aspects of novelty detection, and caused novel-font words to be better recalled. Apomorphine also decreased the amplitude of the novelty-P3a. An increase in D1/D2 receptor activation thus appears to potentiate neural sensitivity to novel stimuli, causing this content to be better encoded.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Apomorfina
/
Agonistas de Dopamina
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Potenciais Evocados P300
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Potenciais Evocados Visuais
/
Neurônios Dopaminérgicos
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
Limite:
Adolescent
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Adult
/
Female
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Humans
/
Male
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article