Multicomponent synthesis of antibacterial dihydropyridin and dihydropyran embelin derivatives.
J Org Chem
; 78(16): 7977-85, 2013 Aug 16.
Article
em En
| MEDLINE
| ID: mdl-23841668
ABSTRACT
A series of dihydropyran and dihydropyridin embelin derivatives were synthesized through a novel and straightforward one-pot protocol based on a three-component reaction with embelin, aldehydes, and cyclic enaminones as synthetic imputs. The type of substituent on the nitrogen atom of the ß-enaminone is key to obtain nitrogenated or oxygenated rings. The obtained compounds were active against Gram-positive bacteria, including multiresistant Staphylococcus aureus clinical isolates.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piranos
/
Di-Hidropiridinas
/
Benzoquinonas
/
Antibacterianos
Tipo de estudo:
Guideline
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article