Platelet-rich plasma reduces postoperative blood loss after cardiopulmonary bypass.
J Thorac Cardiovasc Surg
; 100(2): 281-6, 1990 Aug.
Article
em En
| MEDLINE
| ID: mdl-2385125
ABSTRACT
To study the effect of plasma sequestration and reinfusion of platelet-rich plasma on blood loss after cardiopulmonary bypass, 18 patients undergoing heart operations were randomly selected either to have collected or not to have collected approximately 250 ml of platelet-rich plasma before initiating cardiopulmonary bypass with the use of the Haemonetics Plasma Saving System (Haemonetics Corporation, Braintree, Mass.). All patients had standardized anesthesia and cardiopulmonary bypass. After reversal of heparin, autologous platelet-rich plasma was reinfused in nine patients. Thrombocyte counts, hemoglobin, and hematocrit were calculated before, during, and after cardiopulmonary bypass, and 24 and 48 hours postoperatively. Blood loss and total number of transfusions were recorded. Although 9% of the total platelet volume was removed, there were no hemodynamic complications related to the use of the Haemonetics Plasma Saving System. In both groups, significant low levels of thrombocytes, hemoglobin, and hematocrit were seen after cardiopulmonary bypass. Platelet-rich plasma-reinfused patients had a significantly higher number of platelets after heparin reversal. They also had significantly less blood loss after the operation, necessitating 65% less banked blood products (p less than 0.05). We concluded that reinfusion of autologous platelet-rich plasma may serve as an effective and safe way to restore some of the hematologic derangements after cardiopulmonary bypass.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plaquetas
/
Transfusão de Sangue Autóloga
/
Ponte Cardiopulmonar
/
Procedimentos Cirúrgicos Cardíacos
/
Hemostasia Cirúrgica
Tipo de estudo:
Clinical_trials
/
Observational_studies
Limite:
Humans
/
Middle aged
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article