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Improved synthesis of 17ß-hydroxy-16α-iodo-wortmannin, 17ß-hydroxy-16α-iodoPX866, and the [(131)I] analogue as useful PET tracers for PI3-kinase.
Sun, Duoli; Bhanu Prasad, Basvoju A; Schuber, Paul T; Peng, Zhenghong; Maxwell, David S; Martin, Diana V; Guo, Liwei; Han, Dongmei; Kurihara, Hiroaki; Yang, David J; Gelovani, Juri G; Powis, Garth; Bornmann, William G.
Afiliação
  • Sun D; Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States.
Bioorg Med Chem ; 21(17): 5182-7, 2013 Sep 01.
Article em En | MEDLINE | ID: mdl-23859776
ABSTRACT
An improved method for the synthesis of 17ß-hydroxy-16α-iodo-wortmannin along with the first synthesis of 17ß-hydroxy-16α-iodoPX866 and [(131)I] radiolabeled 17ß-hydroxy-16α-[(131)I]iodo-wortmannin, as potential PET tracers for PI3K was also described. The differences between wortmannin and its iodo analogue were compared by covalently docking each structure to L833 in PI3K.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos Radiofarmacêuticos / Gonanos / Androstadienos Idioma: En Ano de publicação: 2013 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos Radiofarmacêuticos / Gonanos / Androstadienos Idioma: En Ano de publicação: 2013 Tipo de documento: Article