Copper-catalyzed P-arylation via direct coupling of diaryliodonium salts with phosphorus nucleophiles at room temperature.
J Org Chem
; 78(16): 8176-83, 2013 Aug 16.
Article
em En
| MEDLINE
| ID: mdl-23865378
ABSTRACT
A new method for copper-catalyzed P-C bond formation through reaction of phosphorus nucleophiles with diaryliodonium salts at room temperature is described. Most target products are obtained with this method in high yields within a short reaction time of 10 min. It can be easily adapted to large-scale preparations. When unsymmetrical iodonium salts are employed, nucleophilic substitution occurs preferentially on the sterically hindered aromatic ring or the more electron-deficient ring.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
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Compostos Organofosforados
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Fósforo
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Temperatura
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Cobre
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Hidrocarbonetos Iodados
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article