Neurogenin3 activation is not sufficient to direct duct-to-beta cell transdifferentiation in the adult pancreas.

Xiao, Xiangwei; Guo, Ping; Shiota, Chiyo; Prasadan, Krishna; El-Gohary, Yousef; Wiersch, John; Gaffar, Iljana; Gittes, George K

Xiao, Xiangwei; Guo, Ping; Shiota, Chiyo; Prasadan, Krishna; El-Gohary, Yousef; Wiersch, John; Gaffar, Iljana; Gittes, George K.

Afiliação

Xiao X; From the Division of Pediatric Surgery, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224. Electronic address: xiangwei.xiao@chp.edu.
Guo P; From the Division of Pediatric Surgery, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224.
Shiota C; From the Division of Pediatric Surgery, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224.
Prasadan K; From the Division of Pediatric Surgery, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224.
El-Gohary Y; From the Division of Pediatric Surgery, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224.
Wiersch J; From the Division of Pediatric Surgery, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224.
Gaffar I; From the Division of Pediatric Surgery, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224.
Gittes GK; From the Division of Pediatric Surgery, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224. Electronic address: gittesgk@upmc.edu.

J Biol Chem ; 288(35): 25297-25308, 2013 Aug 30.

Article em En | MEDLINE | ID: mdl-23867457

Assuntos

Fatores de Transcrição Hélice-Alça-Hélice Básicos/metabolismo; Transdiferenciação Celular/fisiologia; Células Secretoras de Insulina/metabolismo; Proteínas do Tecido Nervoso/metabolismo; Ductos Pancreáticos/metabolismo; Animais; Fatores de Transcrição Hélice-Alça-Hélice Básicos/genética; Fluoresceínas/farmacologia; Corantes Fluorescentes/farmacologia; Células Secretoras de Insulina/citologia; Camundongos; Camundongos Transgênicos; Proteínas do Tecido Nervoso/genética; Ductos Pancreáticos/citologia; Succinimidas/farmacologia

Palavras-chave

Beta Cell; Flow Cytometry; Pancreas; Reprogramming; Transcription

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ductos Pancreáticos / Células Secretoras de Insulina / Fatores de Transcrição Hélice-Alça-Hélice Básicos / Transdiferenciação Celular / Proteínas do Tecido Nervoso Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2013 Tipo de documento: Article

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