Vitamin B12, folic acid, and bone.
Curr Osteoporos Rep
; 11(3): 213-8, 2013 Sep.
Article
em En
| MEDLINE
| ID: mdl-23873438
ABSTRACT
Vitamin B12 and folic acid deficiency are associated with a higher serum concentration of homocysteine. A high serum homocysteine is a risk factor for fractures. Both vitamins play a role in the remethylation of homocysteine to methionine. The pathophysiology from a high serum homocysteine to fractures is not completely clear, but might involve bone mineral density, bone turnover, bone blood flow, DNA methylation, and/or physical function and fall risk. Genetic variation, especially polymorphisms of the gene encoding for methylenetetrahydrofolate reductase may play a role in homocysteine metabolism and fracture risk. It is uncertain whether supplementation with vitamin B12 and folate can decrease fracture incidence. One double blind clinical trial in post-stroke patients showed that these B vitamins could decrease hip fracture incidence, but the results of further clinical trials should be awaited before a definite conclusion can be drawn.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vitamina B 12
/
Suplementos Nutricionais
/
Fraturas Ósseas
/
Ácido Fólico
Tipo de estudo:
Clinical_trials
/
Prevalence_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article