Consumption of stearidonic acid-rich oil in foods increases red blood cell eicosapentaenoic acid.
J Acad Nutr Diet
; 113(8): 1044-56, 2013 Aug.
Article
em En
| MEDLINE
| ID: mdl-23885702
ABSTRACT
BACKGROUND:
Consumption of soybean oil enriched with stearidonic acid was previously shown to increase eicosapentaenoic acid (EPA) in red blood cells (RBC).OBJECTIVE:
This study was designed to evaluate the effect of stearidonic acid oil used as a food ingredient in baked products and beverages on the RBC fatty acid profile.DESIGN:
This was a randomized, double-blind, controlled, parallel-arm study.PARTICIPANTS:
Healthy men and women 21 to 65 years of age were included. INTERVENTION Participants consumed either negative control (1.5 g/day high-oleic sunflower ethyl ester oil softgel capsules+foods containing 7 g/day high-oleic sunflower oil), positive control (1.5 g/day EPA oil ethyl ester softgel capsules+foods containing 7 g/day high-oleic sunflower oil), or active (1.5 g/day high-oleic sunflower ethyl ester oil softgel capsules+foods containing 7 g/day stearidonic acid soybean oil) for 12 weeks. MAIN OUTCOMEMEASURES:
RBC membrane fatty acid profile (at weeks 0, 2, 4, 6, 8, 10, and 12); fasting serum lipids (weeks -2, 0, 6, 10, and 12); and fasting plasma glucose and insulin (weeks -2, 0, 10, and 12) were assessed. STATISTICAL ANALYSES PERFORMED A repeated measures analysis of covariance was used for continuous variables, and pair-wise comparisons between treatments were adjusted using a step-down Bonferroni method. Fisher's exact or χ(2) tests were used for categorical data.RESULTS:
RBC %EPA throughout the 12-week study were significantly different between all groups. Means at 12 weeks were 0.50%±0.03%, 2.17%±0.21%, and 0.85%±0.05% for control, EPA, and stearidonic acid, respectively. Other efficacy outcome measures were not significantly different among treatment groups.CONCLUSIONS:
Consumption of stearidonic acid-enriched soybean oil incorporated into common foods increased RBC %EPA in healthy men and women. Stearidonic acid soybean oil, a sustainable and accessible source of long-chain n-3, can effectively be used to increase EPA in RBC.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácidos Graxos Ômega-3
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Ácido Eicosapentaenoico
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Eritrócitos
Tipo de estudo:
Clinical_trials
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article