Leptin and urinary leukotriene E4 and 9α,11ß-prostaglandin F2 release after exercise challenge.
Ann Allergy Asthma Immunol
; 111(2): 112-7, 2013 Aug.
Article
em En
| MEDLINE
| ID: mdl-23886229
ABSTRACT
BACKGROUND:
Leptin-related effects on inflammation and bronchial hyperresponsiveness (BHR) in the human airway have not been demonstrated.OBJECTIVES:
To investigate the relationship between the levels of serum leptin and BHR and urinary leukotriene E4 (LTE4) and 9α,11ß-prostaglandin F2 (9α,11ß-PGF(2)) release after exercise challenge in asthmatic children.METHODS:
Eighty-six prepubertal children between 6 and 10 years old were enrolled and divided into 4 groups 19 obese asthmatic children, 25 normal-weight asthmatic children, 21 obese nonasthmatic children, and 21 healthy controls. We measured serum leptin levels and urinary LTE4 and 9α,11ß-PGF2 levels in children before and 30 minutes after the exercise challenge.RESULTS:
Serum leptin levels were significantly higher in obese asthmatic children compared with normal-weight asthmatic children. Significant increases in urinary levels of LTE4 and 9α,11ß-PGF2 were observed in obese asthmatic children after the exercise challenge. Although smaller than in obese asthmatic children, significant increases in the urinary levels of LTE4 and 9α,11ß-PGF2 were also observed in the normal-weight. Asthmatic children Logarithmic serum leptin values were significantly associated with the logarithmic maximum percentage change in forced expiratory volume in 1 second, the logarithmic urinary LTE4 change, and the logarithmic urinary 9α,11ß-PGF2 change from baseline to after exercise in both obese and normal-weight asthmatic children.CONCLUSION:
The serum levels of leptin were significantly associated with BHR and urinary LTE4 and 9α,11ß-PGF2 release induced by exercise challenge in asthmatic children.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Asma Induzida por Exercício
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Dinoprosta
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Leucotrieno E4
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Leptina
Limite:
Child
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article