Peptide pores in lipid bilayers: voltage facilitation pleads for a revised model.
Phys Rev Lett
; 111(2): 028102, 2013 Jul 12.
Article
em En
| MEDLINE
| ID: mdl-23889447
ABSTRACT
We address the problem of antimicrobial peptides that create pores in lipid bilayers, focusing on voltage-temperature dependence of pore opening. Two novel experiments (voltage clamp with alamethicin as an emblematic representative of these peptides and neutron reflectivity of lipid monolayer at solid-water interface under electric field) serve to revise the only current theoretical model. We introduce a general contribution of peptide adsorption and electric field as being responsible for an unbalanced tension of the two bilayer leaflets and we claim that the main entropy cost of one pore opening is due to the corresponding excluded area for lipid translation.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos Catiônicos Antimicrobianos
/
Bicamadas Lipídicas
/
Modelos Químicos
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article