Multilayer nanoparticles for sustained delivery of exenatide to treat type 2 diabetes mellitus.
Biomaterials
; 34(33): 8444-9, 2013 Nov.
Article
em En
| MEDLINE
| ID: mdl-23895999
ABSTRACT
A method for the sustained delivery of exenatide was proposed using nanoparticles (NPs) with a core/shell structure. The interactions between lipid bilayers and Pluronics were utilized to form various NPs using a layer-by-layer approach. Transmittance electron microscopy and dynamic light scattering were used to examine the morphology of the NPs. The in vitro release pattern was observed as a function of changes in the structure of the NPs, and the structural integrity of exenatide released was examined by SDS-PAGE analysis. Pharmacokinetics and antidiabetic effects were also observed with the structural change of NPs using in vivo animal models. In vitro-in vivo correlation was discussed in relation to manipulation of the NP structures.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Peçonhas
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Diabetes Mellitus Tipo 2
/
Nanopartículas
Limite:
Animals
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article