Transcriptomic profiling in childhood H1N1/09 influenza reveals reduced expression of protein synthesis genes.
J Infect Dis
; 208(10): 1664-8, 2013 Nov 15.
Article
em En
| MEDLINE
| ID: mdl-23901082
ABSTRACT
We compared the blood RNA transcriptome of children hospitalized with influenza A H1N1/09, respiratory syncytial virus (RSV) or bacterial infection, and healthy controls. Compared to controls, H1N1/09 patients showed increased expression of inflammatory pathway genes and reduced expression of adaptive immune pathway genes. This was validated on an independent cohort. The most significant function distinguishing H1N1/09 patients from controls was protein synthesis, with reduced gene expression. Reduced expression of protein synthesis genes also characterized the H1N1/09 expression profile compared to children with RSV and bacterial infection, suggesting that this is a key component of the pathophysiological response in children hospitalized with H1N1/09 infection.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biossíntese de Proteínas
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Regulação da Expressão Gênica
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Perfilação da Expressão Gênica
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Influenza Humana
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Vírus da Influenza A Subtipo H1N1
Limite:
Adolescent
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Child
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Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article