Depletion effect and biomembrane budding.
J Biol Phys
; 39(4): 665-71, 2013 Sep.
Article
em En
| MEDLINE
| ID: mdl-23904138
ABSTRACT
Depletion effects are well known to lead to phase separation in microsystems consisting of large and small particles with short-range repulsive interactions that act over macromolecular length scales. The equilibrium mechanics between an enveloped colloidal particle and a biomembrane caused by entropy is investigated by using a continuum model. We show that the favorable contact energy stems from entropy, which is sufficient to drive engulfment of the colloidal particle, and deformation of the biomembrane determines the resistance to the engulfment of the colloidal particle. The engulfment process depends on the ratio of the radii of the larger particle and smaller particles and the bending rigidity. The results show insights into the effects of depletion on biomembrane budding and nanoparticle transportation by a vesicle.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estruturas da Membrana Celular
/
Modelos Biológicos
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article