Metallo-ß-lactamase inhibitory activity of 3-alkyloxy and 3-amino phthalic acid derivatives and their combination effect with carbapenem.
Bioorg Med Chem
; 21(18): 5841-50, 2013 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-23920484
ABSTRACT
3-Alkyloxy and 3-amino phthalic acid derivatives were found to have metallo-ß-lactamase inhibitory activity. Among them, 3-amino phthalic acid derivatives showed both potent activity against metallo-ß-lactamase, IMP-1 inhibitory activity and a strong combination effect with biapenem (BIPM), carbapenem antibiotic. In particular, the 4'-hydroxy-piperidine derivative showed strong IMP-1 inhibitory activity and a combination effect with various antibiotics.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácidos Ftálicos
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Carbapenêmicos
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Inibidores Enzimáticos
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Inibidores de beta-Lactamases
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Antibacterianos
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article