Pressure reflection in the pulmonary circulation by echocardiography in patients with left heart disease indicates reactive pulmonary hypertension.
Int J Cardiol
; 168(4): 4222-7, 2013 Oct 09.
Article
em En
| MEDLINE
| ID: mdl-23932041
ABSTRACT
OBJECTIVES:
The two hemodynamic profiles in left heart disease (LHD) with pulmonary hypertension (PH), passive PH with increased pulmonary venous pressure and reactive PH with increased pulmonary vascular resistance (PVR > 3 Wood units, WU), are difficult to distinguish non-invasively. We hypothesized that echocardiographic signs of pressure reflection (PR) in the pulmonary circulation can be used to diagnose reactive PH. MATERIAL ANDMETHODS:
The study comprised 122 patients divided into three groups patients without PH (No PH, n = 61), patients with LHD, PH and normal PVR (passive PH, n = 29) and patients with LHD, PH and increased PVR (reactive PH, n = 32). Echocardiography and right heart catheterization were performed within 24 h. Three parameters were selected related to PR [the acceleration of flow in the right ventricular outflow tract (RVOT), the interval and the augmentation of pressure between peak RVOT flow and peak RV pressure]. Cutoff values aiming at ruling in (high positive likelihood ratio, PLR) and ruling out (low negative likelihood ratio, NLR) increased PVR were determined using receiver operator characteristic (ROC) curves.RESULTS:
The proportions of the patients with PH and PVR > 3 WU were 50% and 29%. Twenty-one percent had both increased pulmonary capillary wedge pressure and PVR. The area under the ROC curve for the PR parameters was 0.82-0.89. The PLR with ruling in cutoff values ranged from 4.7 to 9.4. The NLR with ruling out cutoff values ranged from 0.20 to 0.12.CONCLUSIONS:
Echocardiographic assessment of PR in patients with LHD can be used to identify or exclude reactive PH.Palavras-chave
AP; Echocardiography; LHD; Left heart disease; PAMP; PASP; PCWP; PH; PR; PVR; Pressure reflection; Pulmonary hypertension; Pulmonary vascular resistance; RHC; RVOT; Reactive pulmonary hypertension; WU; Wood units; augmented pressure; left heart disease; pressure reflection; pulmonary artery mean pressure; pulmonary artery systolic pressure; pulmonary capillary wedge pressure; pulmonary hypertension; pulmonary vascular resistance; right heart catheterization; right ventricular outflow tract
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pressão Propulsora Pulmonar
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Circulação Pulmonar
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Insuficiência Cardíaca
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Hipertensão Pulmonar
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article