Erythroid development in the mammalian embryo.
Blood Cells Mol Dis
; 51(4): 213-9, 2013 Dec.
Article
em En
| MEDLINE
| ID: mdl-23932234
ABSTRACT
Erythropoiesis is the process by which progenitors for red blood cells are produced and terminally differentiate. In all vertebrates, two morphologically distinct erythroid lineages (primitive, embryonic, and definitive, fetal/adult) form successively within the yolk sac, fetal liver, and marrow and are essential for normal development. Red blood cells have evolved highly specialized functions in oxygen transport, defense against oxidation, and vascular remodeling. Here we review key features of the ontogeny of red blood cell development in mammals, highlight similarities and differences revealed by genetic and gene expression profiling studies, and discuss methods for identifying erythroid cells at different stages of development and differentiation.
Palavras-chave
AGM; BFU-E; CFU-E; E#; E-Tmod; EMP; ES; ESRE; EryD; EryP; Erythroid differentiation; Fetal liver; GFP; HPP-CFC; MEP; Mammalian embryo; Primitive erythropoiesis; Transgenic mice; Yolk sac; aortagonadmesonephros; bipotential megakaryocyte/erythroid progenitor; burst-forming unit erythroid; colony-forming cells erythroid; definitive, enucleated erythrocytes; embryonic day post-fertilization; embryonic stem; erythroidmyeloid progenitor; erythroidtropomodulin; extensively self-renewing erythroid; green fluorescent protein; high proliferating progenitors-colony forming cell; primitive (nucleated) erythrocytes
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Eritroides
/
Eritropoese
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article