Inflammation-induced interstitial migration of effector CD4⺠T cells is dependent on integrin αV.
Nat Immunol
; 14(9): 949-58, 2013 Sep.
Article
em En
| MEDLINE
| ID: mdl-23933892
ABSTRACT
Leukocytes must traverse inflamed tissues to effectively control local infection. Although motility in dense tissues seems to be integrin independent and based on actomyosin-mediated protrusion and contraction, during inflammation, changes to the extracellular matrix (ECM) may necessitate distinct motility requirements. Indeed, we found that the interstitial motility of T cells was critically dependent on Arg-Gly-Asp (RGD)-binding integrins in the inflamed dermis. Inflammation-induced deposition of fibronectin was functionally linked to higher expression of integrin αV on effector CD4⺠T cells. By intravital multiphoton imaging, we found that the motility of CD4⺠T cells was dependent on αV expression. Selective blockade or knockdown of αV arrested T helper type 1 (TH1) cells in the inflamed tissue and attenuated local effector function. Our data demonstrate context-dependent specificity of lymphocyte movement in inflamed tissues that is essential for protective immunity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T CD4-Positivos
/
Movimento Celular
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Integrina alfaV
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Inflamação
Limite:
Animals
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article