A short, protecting group-free total synthesis of bruceollines D, E, and J.
Org Lett
; 15(17): 4485-7, 2013 Sep 06.
Article
em En
| MEDLINE
| ID: mdl-23937106
ABSTRACT
A short, protecting group-free total synthesis of bruceollines D, E, and J has been achieved. The enantioselective reduction of bruceolline E with ß-chlorodiisopinocampheylborane delivers both the natural and unnatural enantiomers of bruceolline J in excellent yields and enantioselectivities. Reduction with baker's yeast and sucrose was shown to provide the unnatural enantiomer of bruceolline J in 98% ee.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Produtos Biológicos
/
Compostos Heterocíclicos com 3 Anéis
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article