[Attenuation of cardiac ischemia/reperfusion injury by transient low hydroperoxide pretreatment in rat].
Zhongguo Ying Yong Sheng Li Xue Za Zhi
; 29(3): 247-50, 2013 May.
Article
em Zh
| MEDLINE
| ID: mdl-23940960
ABSTRACT
OBJECTIVE:
To investigate how transient low dose of hydroperoxide pretreatment prevents cardiac ischemia/reperfusion injury.METHODS:
SD rats were divided into 4 groups sham operation (Sham), standard ischemia/reperfusion (I/R), ischemic preconditioning (IPC) and IR preceded by low H2O2 treatment. Cardiac function and injury parameter were compared among groups.RESULTS:
IPC protected reperfusion injury and improved cardiac function. Low H2O2 treatment played a role in cardioprotection similar to IPC. Low H2O2 was indeed generated in the early phase of simulated ischemia and attenuated cytochrome c release induced by high Ca2+ in isolated mitochondria.CONCLUSION:
Low H2O2 plays a critical role in cardioprotection probably by inhibiting mitochondrial permeability transition.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Traumatismo por Reperfusão
/
Precondicionamento Isquêmico
/
Peróxido de Hidrogênio
Limite:
Animals
Idioma:
Zh
Ano de publicação:
2013
Tipo de documento:
Article