Expression analysis of Foxp3 in T cells from bovine leukemia virus infected cattle.
Microbiol Immunol
; 57(8): 600-4, 2013 Aug.
Article
em En
| MEDLINE
| ID: mdl-23945026
ABSTRACT
In the present study, we monitored Foxp3(+) T cells in bovine leukemia virus (BLV)-infected cattle. By flow cytometric analysis, the proportion of Foxp3(+) CD4(+) cells from persistent lymphocytotic cattle was significantly increased compared to control and AL cattle. Interestingly, the proportion of Foxp3(+) CD4(+) cells correlated positively with the increased number of lymphocytes, virus titer and virus load, whereas it inversely correlated with IFN-γ mRNA expression, suggesting that Foxp3(+) CD4(+) T cells in cattle have a potentially immunosuppressive function. Further studies are necessary to elucidate the detailed mechanism behind the increased Treg during BLV infection.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T CD4-Positivos
/
Leucose Enzoótica Bovina
/
Vírus da Leucemia Bovina
/
Fatores de Transcrição Forkhead
Limite:
Animals
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article