Catalytic sp3 C-H oxidation of peptides and their analogues by radical cation salts: from glycine amides to quinolines.

ABSTRACT

A catalytic α-sp(3) C-H oxidation of peptides and glycine amides was achieved under radical cation salt catalysis in the presence of O2, producing a series of substituted quinolines. The scope of this reaction shows good functional group tolerance and high efficiency of the oxidative functionalization.