Vitamin D in childhood cancer: a promising anticancer agent?
Pediatr Endocrinol Rev
; 10(4): 485-93, 2013 Jul.
Article
em En
| MEDLINE
| ID: mdl-23957199
ABSTRACT
Children diagnosed and treated for cancer are vulnerable to Vitamin D deficiency depending on many factors. The Vitamin D status in children with cancer has been mostly regarded as a contributory factor for skeletal pathologies so far. However, the calcitriol was found to promote cell differentiation, inhibit malignant proliferation, and exhibit antiinflammatory, proapoptotic and antiangiogenic properties. In addition to this, numerous epidemiological studies link Vitamin D and cancer and indicate to possible role of Vitamin D in cancer pathogenesis and progression. This article aims to provide an overview of the possible role of Vitamin D deficiency in childhood cancer in terms of prevention and treatment.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vitamina D
/
Deficiência de Vitamina D
/
Neoplasias
/
Antineoplásicos
Limite:
Child
/
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article