Completing the folate biosynthesis pathway in Plasmodium falciparum: p-aminobenzoate is produced by a highly divergent promiscuous aminodeoxychorismate lyase.
Biochem J
; 455(2): 149-55, 2013 Oct 15.
Article
em En
| MEDLINE
| ID: mdl-23957380
ABSTRACT
Enzymes that produce or recycle folates are the targets of widely used antimalarial drugs. Despite the interest in the folate metabolism of Plasmodium falciparum, the molecular identification of ADCL (aminodeoxychorismate lyase), which synthesizes the p-aminobenzoate moiety of folate, remained unresolved. In the present study, we demonstrate that the plasmodial gene PF14_0557 encodes a functional ADCL and report a characterization of the recombinant enzyme.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plasmodium falciparum
/
Proteínas de Protozoários
/
Para-Aminobenzoatos
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Ácido Fólico
/
Oxo-Ácido-Liases
Limite:
Animals
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article