Gag-dependent enrichment of HIV-1 RNA near the uropod membrane of polarized T cells.
J Virol
; 87(21): 11912-5, 2013 Nov.
Article
em En
| MEDLINE
| ID: mdl-23966405
ABSTRACT
The enrichment of HIV-1 macromolecules at the uropod of polarized T cells can significantly promote virus assembly and cell-mediated infection. Using live-cell fluorescence microscopy, we demonstrate that full-length HIV-1 RNA is enriched at the uropod membrane; furthermore, the presence of HIV-1 Gag containing a functional nucleocapsid domain is necessary for this HIV-1 RNA enrichment. The results from these studies provide novel insights into the mechanism of HIV-1 replication in polarized T cells.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
RNA Viral
/
Linfócitos T CD4-Positivos
/
Membrana Celular
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HIV-1
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Montagem de Vírus
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Substâncias Macromoleculares
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Produtos do Gene gag do Vírus da Imunodeficiência Humana
Limite:
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article