Esclerose Lateral Amiotrófica/genética; Fosfolipase C delta/genética; Esclerose Lateral Amiotrófica/enzimologia; Esclerose Lateral Amiotrófica/metabolismo; Animais; Modelos Animais de Doenças; Humanos; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Camundongos Transgênicos; Neurônios/metabolismo; Neurônios/patologia; Fosfolipase C delta/metabolismo; Medula Espinal/metabolismo; Medula Espinal/patologia; Superóxido Dismutase/genética; Superóxido Dismutase/metabolismo; Superóxido Dismutase-1; Análise de Sobrevida

ALS; AMPA; Amyotrophic lateral sclerosis; C9orf72; DPP6; ELP3; ER; Excitotoxicity; FUS/TLS; GFAP; IP(3); ITPR2; Motor neuron disease; Neurogenetics; Nuclear shrinkage; PBS; PCR; PFN1; PLCD1; POAG; Phospholipase C delta 1; SDS-PAGE; SNP; SOD1; SOD1-G93A mice; TAR-DNA binding protein 43; TARDBP; UBQLN2; UNC13a; amyotrophic lateral sclerosis; chromosome 9 open reading frame 72; dipeptidyl-peptidase 6; elongator protein 3; endoplasmic reticulum; fused in sarcoma/translocated in liposarcoma; glial fibrillary acidic protein; inositol 1,4,5-trisphosphate; inositol 1,4,5-trisphosphate receptor 2; phosphate buffered saline; phosphoinositide phospholipase C; polymerase chain reaction; primary open-angle glaucoma; profilin 1; single nucleotide polymorphism; sodium dodecyl sulfate polyacrylamide gel electrophoresis; superoxide dismutase 1; ubiquilin 2; unc-13 homolog A; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid