Efficient prevention strategy against the development of a palmar-plantar erythrodysesthesia during chemotherapy.
Skin Pharmacol Physiol
; 27(2): 66-70, 2014.
Article
em En
| MEDLINE
| ID: mdl-23969763
ABSTRACT
BACKGROUND:
Pegylated liposomal doxorubicin (PLD) is a highly efficient chemotherapeutic; however, it induces dermal side effects such as palmar-plantar erythrodysesthesia (PPE) in up to 80% of cases, probably by being emitted with the sweat onto the skin surface.AIM:
The aim of the present study was to examine whether a topically applied ointment containing antioxidants with a high radical protection factor is able to prevent the formation of PPE.METHODS:
Twenty patients suffering from ovarian carcinoma and treated with PLD were observed.RESULTS:
60% of the patients tolerated the regular application of the cream and developed no PPE. The remaining 40% interrupted the application. Six of them developed PPE and resumed ointment application thereafter. In these cases the PPE disappeared or was strongly reduced.CONCLUSION:
The results of the observation clearly demonstrate that topical application of the ointment is an efficient strategy against the development of PPE during chemotherapy with PLD.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
/
Doxorrubicina
/
Síndrome Mão-Pé
/
Antibióticos Antineoplásicos
/
Antioxidantes
Limite:
Aged
/
Female
/
Humans
/
Middle aged
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article