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Synthesis and platelet aggregation inhibitory effects of N-[(1H-pyrazol-1-yl)alkyl]benzoylamides.
Ferroni, R; Milani, L; Simoni, D; Orlandini, P; Bottura, M; Bardi, A; Guarneri, M.
Afiliação
  • Ferroni R; Dipartimento di Scienze Farmaceutiche, Universitá di Ferrara, Italy.
Arzneimittelforschung ; 40(6): 705-9, 1990 Jun.
Article em En | MEDLINE | ID: mdl-2397007
A series of N-[(1H-pyrazol-1-yl)alkyl]benzoylamides was synthesized and tested in vitro for their inhibitory effects on adenosine diphosphate-, collagen-, arachidonic acid- and thrombin-induced aggregation of human platelets. Among them, N-[(1H-pyrazol-1-yl)butyl]benzoylamide (Ve) was found to have the most potent inhibitory activity. The structure-activity relationships are reported. The biological activity of the title compounds is reported in parallel with that of a known inhibitor of thromboxane A2 synthetase.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores da Agregação Plaquetária Limite: Humans Idioma: En Ano de publicação: 1990 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores da Agregação Plaquetária Limite: Humans Idioma: En Ano de publicação: 1990 Tipo de documento: Article