BreakTrans: uncovering the genomic architecture of gene fusions.
Genome Biol
; 14(8): R87, 2013 Aug 23.
Article
em En
| MEDLINE
| ID: mdl-23972288
ABSTRACT
Producing gene fusions through genomic structural rearrangements is a major mechanism for tumor evolution. Therefore, accurately detecting gene fusions and the originating rearrangements is of great importance for personalized cancer diagnosis and targeted therapy. We present a tool, BreakTrans, that systematically maps predicted gene fusions to structural rearrangements. Thus, BreakTrans not only validates both types of predictions, but also provides mechanistic interpretations. BreakTrans effectively validates known fusions and discovers novel events in a breast cancer cell line. Applying BreakTrans to 43 breast cancer samples in The Cancer Genome Atlas identifies 90 genomically validated gene fusions. BreakTrans is available at http//bioinformatics.mdanderson.org/main/BreakTrans.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Software
/
Neoplasias da Mama
/
Proteínas de Fusão Oncogênica
/
Fusão Oncogênica
/
Pontos de Quebra do Cromossomo
Tipo de estudo:
Diagnostic_studies
Limite:
Female
/
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article