[A case of elderly-onset type 1 diabetes mellitus: negative for antiglutamic acid dehydrogenase antibody and positive insulinoma-associated tyrosine phosphatase-like protein-2 antibody].
Nihon Ronen Igakkai Zasshi
; 50(3): 404-8, 2013.
Article
em Ja
| MEDLINE
| ID: mdl-23979349
ABSTRACT
An 83-year-old Japanese woman given a diagnosis of type 2 diabetes mellitus 3 years previously was hospitalized for markedly elevated plasma glucose (386 mg/dl) and glycated hemoglobin (9.3%) levels. Laboratory study results showed urinary connecting peptide immunoreactivity (CPR) concentrations of 8.9 µg/day and serum CPR levels <0.2 ng/ml before and 0.3 ng/ml 6 min after glucagon administration, indicating decreased insulin secretion. Although antiglutamic acid dehydrogenase (GAD) antibody levels were negative, insulinoma-associated tryrosine phosphatase-like protein-2 (IA-2) antibody levels were positive (50 U/ml), leading to a diagnosis of type 1 diabetes mellitus. Furthermore, human leukocyte antigen (HLA) typing revealed DRB1*0901, a diabetes-susceptibility gene. Intensive insulin therapy was initiated. This was a rare case of elderly-onset type 1 diabetes.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autoanticorpos
/
Diabetes Mellitus Tipo 1
/
Proteínas Tirosina Fosfatases Classe 8 Semelhantes a Receptores
/
Glutamato Desidrogenase
Tipo de estudo:
Diagnostic_studies
/
Risk_factors_studies
Limite:
Aged80
/
Female
/
Humans
Idioma:
Ja
Ano de publicação:
2013
Tipo de documento:
Article