[Role of stress in myocardial protection of ischemic preconditioning].
Zhong Nan Da Xue Xue Bao Yi Xue Ban
; 38(8): 804-8, 2013 Aug.
Article
em Zh
| MEDLINE
| ID: mdl-23981998
ABSTRACT
OBJECTIVE:
To determine the role of stress in myocardial protection of ischemic preconditioning (IPC).METHODS:
Thirty rabbits were randomly divided into an IPC group, an etomidate (Etom) group, an ischemic/reperfusion (IR) group, a methylprednisolone (MP) group and a sham group. The ratio of infarction size versus risk area (infarct/risk) was calculated. The elevations of the serum creatine kinase (CK) activity and cardiac troponin I (cTnI) concentrations as well as the serum cortisol concentrations were measured.RESULTS:
The percentages of infarct/risk in the IPC group, the MP group, the IR group, and the Etom group were (5.86±2.81)%, (11.28±3.62)%, (26.79±4.53)%, and (18.19±3.72)%, respectively. The elevations of the serum CK activity in the IPC group, the MP group, the IR group, and the Etom group were (255±89), (314±160), (855±371), and (768±404) U/L, respectively. The elevations of serum cTnI concentrations in the IPC group, the MP group, the IR group, and the Etom group were (3.6±0.6),(6.1±2.2), (8.1±3.6), and (6.4±1.6) µg/L, respectively. Those indicators among the groups were significantly different (P<0.05). Cortisol reaction was markedly diminished in the Etom group.CONCLUSION:
A blunted cortisol reaction can markedly reduce the benefit of IPC while methylprednisolone shows cardioprotective effects, suggesting that stress might be involved in the myocardial protection of IPC.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estresse Fisiológico
/
Traumatismo por Reperfusão Miocárdica
/
Precondicionamento Isquêmico Miocárdico
/
Infarto do Miocárdio
Limite:
Animals
Idioma:
Zh
Ano de publicação:
2013
Tipo de documento:
Article