Acute and chronic effects of diphenhydramine and sertraline mixtures in Ceriodaphnia dubia.
Environ Toxicol Chem
; 32(12): 2866-9, 2013 Dec.
Article
em En
| MEDLINE
| ID: mdl-23996615
ABSTRACT
Ceriodaphnia dubia were tested to evaluate the acute and chronic interactive effects of diphenhydramine and sertraline. Observed effects were compared with 2 reference toxicity models, the concentration addition model and the independent action model. Results indicate that the 2 drugs exhibit additive toxicity in C. dubia. In some cases, individually sublethal concentrations of the chemicals resulted in 100% mortality when combined, demonstrating the potentially severe impact of trace environmental contaminants.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Poluentes Químicos da Água
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Inibidores Seletivos de Recaptação de Serotonina
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Sertralina
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Cladocera
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Difenidramina
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Antagonistas dos Receptores Histamínicos H1
Limite:
Animals
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article