Design and synthesis of MMP inhibitors with appended fluorescent tags for imaging and visualization of matrix metalloproteinase enzymes.
Bioorg Med Chem Lett
; 23(20): 5566-70, 2013 Oct 15.
Article
em En
| MEDLINE
| ID: mdl-23999043
ABSTRACT
We describe the synthesis, MMP-2 and 9 potency, and in vitro evaluation of a series of α-sulfone hydroxmate MMP inhibitors conjugated to a series of dyes with different absorption/emission lamina maxima's that can be used to visualize tumors.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Desenho de Fármacos
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Metaloproteinase 2 da Matriz
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Metaloproteinase 9 da Matriz
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Inibidores de Metaloproteinases de Matriz
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Corantes Fluorescentes
Limite:
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article