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Tailoring chronic pain treatments for the elderly: are we prepared for the challenge?
Arneric, Stephen P; Laird, Jennifer M A; Chappell, Amy S; Kennedy, Jeffrey D.
Afiliação
  • Arneric SP; Eli Lilly & Company, Neuroscience, Indianapolis, IN 46285, USA. Electronic address: Arneric_Stephen@Lilly.com.
  • Laird JM; Eli Lilly & Company, Neuroscience, Indianapolis, IN 46285, USA; Dept of Pharmacology & Experimental Therapeutics and Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec H3G 1Y6, Canada.
  • Chappell AS; Eli Lilly & Company, Neuroscience, Indianapolis, IN 46285, USA.
  • Kennedy JD; Eli Lilly & Company, Neuroscience, Indianapolis, IN 46285, USA.
Drug Discov Today ; 19(1): 8-17, 2014 Jan.
Article em En | MEDLINE | ID: mdl-24001595
Chronic pain is increasingly recognized as a disease and accounts for substantial suffering and disability worldwide. The aging 'baby-boomer' generation is creating a tsunami of elderly patients (>65 years old) for global healthcare systems (between 2010 and 2030). The phenotypic expression of chronic pain in the elderly can be influenced by co-morbid diseases (e.g. diabetes, cancer, depression, Alzheimer's disease, etc.), changes in physiological competency (e.g. drug metabolism/elimination) or cognitive reserve. Will a shift in the drug discovery paradigm be required to improve efficacy, side-effects or positively impact quality of life (QoL) in the elderly with chronic pain? This review highlights a number of potential pitfalls that should be considered when delivering valued pain relief medicines tailored for the elderly.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Expectativa de Vida / Dor Crônica / Manejo da Dor Tipo de estudo: Diagnostic_studies Limite: Aged / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Expectativa de Vida / Dor Crônica / Manejo da Dor Tipo de estudo: Diagnostic_studies Limite: Aged / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article