Exogenous hormone use, reproductive history and risk of adult myeloid leukaemia.
Br J Cancer
; 109(7): 1895-8, 2013 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-24002589
ABSTRACT
BACKGROUND:
A hormonal aetiology is one explanation for the lower incidence of myeloid leukaemia in women compared with men.METHODS:
In this population-based case-control study, we evaluated associations between exogenous hormone use and reproductive history and myeloid leukaemia, overall and by disease subtype.RESULTS:
We observed a suggestive association between oral contraceptive use and acute myeloid leukaemia (odds ratio=0.55, 95% confidence interval=0.32-0.96). Hormone replacement therapy and reproductive factors were not associated with risk.CONCLUSION:
Despite the biological plausibility for a role of oestrogen in leukaemogenesis, other aetiologic factors are likely to explain the differing incidence rates in males and females.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leucemia Mieloide
/
História Reprodutiva
/
Anticoncepcionais Orais
/
Terapia de Reposição Hormonal
/
Estrogênios
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article