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Computational design of ligand-binding proteins with high affinity and selectivity.
Tinberg, Christine E; Khare, Sagar D; Dou, Jiayi; Doyle, Lindsey; Nelson, Jorgen W; Schena, Alberto; Jankowski, Wojciech; Kalodimos, Charalampos G; Johnsson, Kai; Stoddard, Barry L; Baker, David.
Afiliação
  • Tinberg CE; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
  • Khare SD; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
  • Dou J; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.
  • Doyle L; Graduate Program in Biological Physics, Structure, and Design, University of Washington, Seattle, WA 98195, USA.
  • Nelson JW; Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
  • Schena A; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.
  • Jankowski W; Institute of Chemical Sciences and Engineering, Institute of Bioengineering, National Centre of Competence in Research (NCCR) of Chemical Biology, École Polytechnique Fédérale de Laussane (EPFL), Laussane, Switzerland.
  • Kalodimos CG; Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA.
  • Johnsson K; Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA.
  • Stoddard BL; Institute of Chemical Sciences and Engineering, Institute of Bioengineering, National Centre of Competence in Research (NCCR) of Chemical Biology, École Polytechnique Fédérale de Laussane (EPFL), Laussane, Switzerland.
  • Baker D; Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Nature ; 501(7466): 212-216, 2013 Sep 12.
Article em En | MEDLINE | ID: mdl-24005320
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Simulação por Computador / Desenho de Fármacos / Proteínas / Digoxigenina Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2013 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Simulação por Computador / Desenho de Fármacos / Proteínas / Digoxigenina Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2013 Tipo de documento: Article