Systemic diagnostic testing in patients with apparently isolated uveal coloboma.
Am J Ophthalmol
; 156(6): 1159-1168.e4, 2013 Dec.
Article
em En
| MEDLINE
| ID: mdl-24012100
ABSTRACT
PURPOSE:
To investigate the frequency and types of systemic findings in patients with apparently isolated uveal coloboma.DESIGN:
Cross-sectional observational study.METHODS:
setting:
Single-center ophthalmic genetics clinic. study population Ninety-nine patients with uveal coloboma seen at the National Eye Institute. observational procedure Results of audiology testing, echocardiogram, brain magnetic resonance imaging, renal ultrasound, and total spine radiographs. main outcomemeasure:
Prevalence of abnormal findings on systemic testing.RESULTS:
Uveal coloboma affected only the anterior segment in 8 patients, only the posterior segment in 23 patients, and both anterior and posterior segments in 68 patients. Best-corrected visual acuity (BCVA) of eyes with coloboma was ≥20/40 in 45% of eyes; 23% of eyes had BCVA of ≤20/400. The majority of patients (74%) had good vision (>20/60) in at least 1 eye. Ten of the 19 patients (53%) who underwent echocardiography had abnormalities, with ventral septal defects being the most prevalent. Abnormal findings were observed in 5 of 72 patients (7%) who had a renal ultrasound and in 5 of 29 patients (17%) who underwent a brain MRI. Audiology testing revealed abnormalities in 13 of 75 patients (17%), and spine radiographs showed anomalies in 10 of 77 patients (13%). Most findings required no acute intervention.CONCLUSIONS:
Although some patients with coloboma had evidence of extraocular abnormalities, the majority of findings on routine clinical examination did not require acute intervention, but some warranted follow-up. Results from the systemic evaluation of patients with coloboma should be interpreted with caution and in view of their clinical context.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Anormalidades Múltiplas
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Coloboma
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Segmento Posterior do Olho
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Segmento Anterior do Olho
Tipo de estudo:
Diagnostic_studies
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Observational_studies
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Prevalence_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article