Profiling solute carrier transporters in the human blood-brain barrier.
Clin Pharmacol Ther
; 94(6): 636-9, 2013 Dec.
Article
em En
| MEDLINE
| ID: mdl-24013810
ABSTRACT
The neuroprotective function of the blood-brain barrier (BBB) presents a major challenge for drug delivery to the central nervous system (CNS). Critical to this function, BBB membrane transporters include the ATP-binding cassette (ABC) transporters, which limit drug penetration across the BBB, and the less-well-studied solute carrier (SLC) transporters. In this work, expression profiling of 359 SLC transporters, comparative expression analysis with kidney and liver, and immunoassays in brain microvessels (BMVs) identified previously unknown transporters at the human BBB.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Membrana Transportadoras
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Encéfalo
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Barreira Hematoencefálica
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Microvasos
Limite:
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article