Telomerase reverse transcriptase promoter mutations in bladder cancer: high frequency across stages, detection in urine, and lack of association with outcome.

Allory, Yves; Beukers, Willemien; Sagrera, Ana; Flández, Marta; Marqués, Miriam; Márquez, Mirari; van der Keur, Kirstin A; Dyrskjot, Lars; Lurkin, Irene; Vermeij, Marcel; Carrato, Alfredo; Lloreta, Josep; Lorente, José A; Carrillo-de Santa Pau, Enrique; Masius, Roy G; Kogevinas, Manolis; Steyerberg, Ewout W; van Tilborg, Angela A G; Abas, Cheno; Orntoft, Torben F; Zuiverloon, Tahlita C M; Malats, Núria; Zwarthoff, Ellen C; Real, Francisco X

Allory, Yves; Beukers, Willemien; Sagrera, Ana; Flández, Marta; Marqués, Miriam; Márquez, Mirari; van der Keur, Kirstin A; Dyrskjot, Lars; Lurkin, Irene; Vermeij, Marcel; Carrato, Alfredo; Lloreta, Josep; Lorente, José A; Carrillo-de Santa Pau, Enrique; Masius, Roy G; Kogevinas, Manolis; Steyerberg, Ewout W; van Tilborg, Angela A G; Abas, Cheno; Orntoft, Torben F; Zuiverloon, Tahlita C M; Malats, Núria; Zwarthoff, Ellen C; Real, Francisco X.

Afiliação

Allory Y; Epithelial Carcinogenesis Group, Molecular Pathology Program, CNIO (Spanish National Cancer Research Center), Madrid, Spain; Université Paris-Est Créteil, Institut Mondor de Recherche Biomédicale, Créteil, France.
Beukers W; Department of Pathology, Erasmus MC, Rotterdam, The Netherlands.
Sagrera A; Epithelial Carcinogenesis Group, Molecular Pathology Program, CNIO (Spanish National Cancer Research Center), Madrid, Spain.
Flández M; Epithelial Carcinogenesis Group, Molecular Pathology Program, CNIO (Spanish National Cancer Research Center), Madrid, Spain.
Marqués M; Epithelial Carcinogenesis Group, Molecular Pathology Program, CNIO (Spanish National Cancer Research Center), Madrid, Spain.
Márquez M; Genetic and Molecular Epidemiology Group, Human Cancer Genetics Program, CNIO (Spanish National Cancer Research Center), Madrid, Spain.
van der Keur KA; Department of Pathology, Erasmus MC, Rotterdam, The Netherlands.
Dyrskjot L; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.
Lurkin I; Department of Pathology, Erasmus MC, Rotterdam, The Netherlands.
Vermeij M; Department of Pathology, Erasmus MC, Rotterdam, The Netherlands.
Carrato A; Medical Oncology Department, Ramón y Cajal University Hospital, Madrid, Spain.
Lloreta J; Department of Pathology, Hospital del Mar-Parc de Salut Mar, Barcelona, Spain; Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.
Lorente JA; Urology Service, Hospital del Mar-Parc de Salut Mar, Barcelona, Spain.
Carrillo-de Santa Pau E; Epithelial Carcinogenesis Group, Molecular Pathology Program, CNIO (Spanish National Cancer Research Center), Madrid, Spain.
Masius RG; Department of Pathology, Erasmus MC, Rotterdam, The Netherlands.
Kogevinas M; Centre de Recerca d'Epidemiologia Ambiental, Barcelona, Spain; IMIM-Institut de Recerca Hospital del Mar, Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain; National School of Public Health, Athens, Greece.
Steyerberg EW; Department of Public Health, Erasmus MC, Rotterdam, The Netherlands.
van Tilborg AA; Department of Pathology, Erasmus MC, Rotterdam, The Netherlands.
Abas C; Department of Pathology, Erasmus MC, Rotterdam, The Netherlands; Epithelial Carcinogenesis Group, Molecular Pathology Program, CNIO (Spanish National Cancer Research Center), Madrid, Spain.
Orntoft TF; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.
Zuiverloon TC; Department of Pathology, Erasmus MC, Rotterdam, The Netherlands.
Malats N; Genetic and Molecular Epidemiology Group, Human Cancer Genetics Program, CNIO (Spanish National Cancer Research Center), Madrid, Spain.
Zwarthoff EC; Department of Pathology, Erasmus MC, Rotterdam, The Netherlands.
Real FX; Epithelial Carcinogenesis Group, Molecular Pathology Program, CNIO (Spanish National Cancer Research Center), Madrid, Spain; Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain. Electronic address: preal@cnio.es.

Eur Urol ; 65(2): 360-6, 2014 Feb.

Article em En | MEDLINE | ID: mdl-24018021

Assuntos

Biomarcadores Tumorais/genética; Mutação; Regiões Promotoras Genéticas; Telomerase/genética; Neoplasias da Bexiga Urinária/enzimologia; Neoplasias da Bexiga Urinária/genética; Idoso; Biomarcadores Tumorais/urina; Linhagem Celular Tumoral; Análise Mutacional de DNA; Progressão da Doença; Intervalo Livre de Doença; Feminino; Predisposição Genética para Doença; Testes Genéticos/métodos; Humanos; Masculino; Gradação de Tumores; Recidiva Local de Neoplasia; Estadiamento de Neoplasias; Países Baixos; Fenótipo; Valor Preditivo dos Testes; RNA Mensageiro/urina; Estudos Retrospectivos; Reação em Cadeia da Polimerase Via Transcriptase Reversa; Fatores de Risco; Espanha; Telomerase/urina; Fatores de Tempo; Neoplasias da Bexiga Urinária/mortalidade; Neoplasias da Bexiga Urinária/patologia; Neoplasias da Bexiga Urinária/terapia; Neoplasias da Bexiga Urinária/urina

Palavras-chave

Bladder cancer; Clinical end point; Somatic mutations; TERT gene; Urine-based diagnosis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Bexiga Urinária / Biomarcadores Tumorais / Regiões Promotoras Genéticas / Telomerase / Mutação Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male País/Região como assunto: Europa Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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