In vitro susceptibility of Aspergillus fumigatus to isavuconazole: correlation with itraconazole, voriconazole, and posaconazole.
Antimicrob Agents Chemother
; 57(11): 5778-80, 2013 Nov.
Article
em En
| MEDLINE
| ID: mdl-24041890
ABSTRACT
Triazoles are first-line agents for treating aspergillosis. The prevalence of azole resistance in Aspergillus fumigatus is increasing, and cross-resistance is a growing concern. In this study, the susceptibilities of 40 A. fumigatus clinical isolates were tested by using the CLSI method with amphotericin B, itraconazole, voriconazole, posaconazole, and the new triazole isavuconazole. Isavuconazole MICs were higher in strains with reduced susceptibilities to other triazoles, mirroring changes in voriconazole susceptibility. Isavuconazole MICs differed depending on the Cyp51A substitution.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piridinas
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Aspergillus fumigatus
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Triazóis
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Proteínas Fúngicas
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Substituição de Aminoácidos
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Sistema Enzimático do Citocromo P-450
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Farmacorresistência Fúngica
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Antifúngicos
/
Nitrilas
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article