Connectivity patterns of pallidal DBS electrodes in focal dystonia: a diffusion tensor tractography study.
Neuroimage
; 84: 435-42, 2014 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-24045076
ABSTRACT
Deep brain stimulation (DBS) of the internal pallidal segment (GPi globus pallidus internus) is gold standard treatment for medically intractable dystonia, but detailed knowledge of mechanisms of action is still not available. There is evidence that stimulation of ventral and dorsal GPi produces opposite motor effects. The aim of this study was to analyse connectivity profiles of ventral and dorsal GPi. Probabilistic tractography was initiated from DBS electrode contacts in 8 patients with focal dystonia and connectivity patterns compared. We found a considerable difference in anterior-posterior distribution of fibres along the mesial cortical sensorimotor areas between the ventral and dorsal GPi connectivity. This finding of distinct GPi connectivity profiles further confirms the clinical evidence that the ventral and dorsal GPi belong to different functional and anatomic motor subsystems. Their involvement could play an important role in promoting clinical DBS effects in dystonia.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Distúrbios Distônicos
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Estimulação Encefálica Profunda
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Imagem de Tensor de Difusão
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Globo Pálido
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Fibras Nervosas Mielinizadas
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Rede Nervosa
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article