3-(2,5-Di-methyl-phen-yl)-8-meth-oxy-2-oxo-1-aza-spiro-[4.5]dec-3-en-4-yl 3-(2-bromo-4-fluoro-phen-yl)acrylate.
Acta Crystallogr Sect E Struct Rep Online
; 69(Pt 7): o1064-5, 2013.
Article
em En
| MEDLINE
| ID: mdl-24046635
ABSTRACT
In the title compound, C27H27BrFNO4, which is an inhibitor of acetyl-CoA carboxyl-ase, the cyclo-hexane ring displays a chair comformation with the spiro-C and meth-oxy-bearing C atoms deviating by 0.681â
(7) and -0.655â
(1)â
Å, resppectively, from the mean plane formed by the other four C atoms of the spiro-C6 ring. The mean planes of the cyclo-hexane and 2-bromo-4-fluoro-phenyl rings are nearly perpendicular to that of the pyrrolidine ring, making dihedral angles 89.75â
(6) and 87.60â
(9)°, respectively. In the crystal, mol-ecules are linked via pairs of N-Hâ¯O hydrogen bonds, forming inversion dimers.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article