Cytotoxicity and modes of action of three naturally occurring xanthones (8-hydroxycudraxanthone G, morusignin I and cudraxanthone I) against sensitive and multidrug-resistant cancer cell lines.

Kuete, Victor; Sandjo, Louis P; Ouete, Judith L Nantchouang; Fouotsa, Hugues; Wiench, Benjamin; Efferth, Thomas

Kuete, Victor; Sandjo, Louis P; Ouete, Judith L Nantchouang; Fouotsa, Hugues; Wiench, Benjamin; Efferth, Thomas.

Afiliação

Kuete V; Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Staudinger Weg 5, 55128 Mainz, Germany; Department of Biochemistry, Faculty of Science, University of Dschang, Cameroon.
Sandjo LP; Department of Biochemistry, Faculty of Science, University of Yaoundé I, Cameroon.
Ouete JL; Department of Biochemistry, Faculty of Science, University of Yaoundé I, Cameroon.
Fouotsa H; Department of Biochemistry, Faculty of Science, University of Yaoundé I, Cameroon.
Wiench B; Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Staudinger Weg 5, 55128 Mainz, Germany.
Efferth T; Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Staudinger Weg 5, 55128 Mainz, Germany. Electronic address: efferth@uni-mainz.de.

Phytomedicine ; 21(3): 315-22, 2014 Feb 15.

Article em En | MEDLINE | ID: mdl-24075210

Assuntos

Resistência a Múltiplos Medicamentos/efeitos dos fármacos; Resistencia a Medicamentos Antineoplásicos/efeitos dos fármacos; Garcinia/química; Neoplasias/tratamento farmacológico; Fitoterapia; Extratos Vegetais/uso terapêutico; Xantonas/uso terapêutico; Antineoplásicos Fitogênicos/farmacologia; Antineoplásicos Fitogênicos/uso terapêutico; Apoptose; Caspases/metabolismo; Pontos de Checagem do Ciclo Celular/efeitos dos fármacos; Linhagem Celular Tumoral; Células Hep G2; Humanos; Potencial da Membrana Mitocondrial/efeitos dos fármacos; Neoplasias/metabolismo; Extratos Vegetais/farmacologia; Xantonas/farmacologia

Palavras-chave

Apoptosis; Cell cycle distribution; Cudraxanthone I; Cytotoxicity; Mitochondrial membrane potential; Natural products; Xanthones

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Resistência a Múltiplos Medicamentos / Resistencia a Medicamentos Antineoplásicos / Garcinia / Xantonas / Fitoterapia / Neoplasias Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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