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Discovery of a novel sub-class of ROMK channel inhibitors typified by 5-(2-(4-(2-(4-(1H-Tetrazol-1-yl)phenyl)acetyl)piperazin-1-yl)ethyl)isobenzofuran-1(3H)-one.
Tang, Haifeng; de Jesus, Reynald K; Walsh, Shawn P; Zhu, Yuping; Yan, Yan; Priest, Birgit T; Swensen, Andrew M; Alonso-Galicia, Magdalena; Felix, John P; Brochu, Richard M; Bailey, Timothy; Thomas-Fowlkes, Brande; Zhou, Xiaoyan; Pai, Lee-Yuh; Hampton, Caryn; Hernandez, Melba; Owens, Karen; Roy, Sophie; Kaczorowski, Gregory J; Yang, Lihu; Garcia, Maria L; Pasternak, Alexander.
Afiliação
  • Tang H; Department of Medicinal Chemistry, Rahway, NJ 07065, United States; Department of Ions Channels, Cardiovascular Disease, Rahway, NJ 07065, United States; Department of Drug Metabolism and Pharmacology, Rahway, NJ 07065, United States; Department of Merck Research Laboratories, Rahway, NJ 07065, United States. Electronic address: haifeng_tang@merck.com.
Bioorg Med Chem Lett ; 23(21): 5829-32, 2013 Nov 01.
Article em En | MEDLINE | ID: mdl-24075732
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzofuranos / Canais de Potássio Corretores do Fluxo de Internalização Limite: Animals / Humans Idioma: En Ano de publicação: 2013 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzofuranos / Canais de Potássio Corretores do Fluxo de Internalização Limite: Animals / Humans Idioma: En Ano de publicação: 2013 Tipo de documento: Article