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The MLH1 c.-27C>A and c.85G>T variants are linked to dominantly inherited MLH1 epimutation and are borne on a European ancestral haplotype.
Kwok, Chau-To; Vogelaar, Ingrid P; van Zelst-Stams, Wendy A; Mensenkamp, Arjen R; Ligtenberg, Marjolijn J; Rapkins, Robert W; Ward, Robyn L; Chun, Nicolette; Ford, James M; Ladabaum, Uri; McKinnon, Wendy C; Greenblatt, Marc S; Hitchins, Megan P.
Afiliação
  • Kwok CT; Adult Cancer Program, Lowy Cancer Research Centre, Prince of Wales Clinical School, University of New South Wales, Sydney, NSW, Australia.
  • Vogelaar IP; Department of Human Genetics, Radboud University Medical Centre, Nijmegen, The Netherlands.
  • van Zelst-Stams WA; Department of Human Genetics, Radboud University Medical Centre, Nijmegen, The Netherlands.
  • Mensenkamp AR; Department of Human Genetics, Radboud University Medical Centre, Nijmegen, The Netherlands.
  • Ligtenberg MJ; 1] Department of Human Genetics, Radboud University Medical Centre, Nijmegen, The Netherlands [2] Department of Pathology, Radboud University Medical Centre, Nijmegen, The Netherlands.
  • Rapkins RW; Adult Cancer Program, Lowy Cancer Research Centre, Prince of Wales Clinical School, University of New South Wales, Sydney, NSW, Australia.
  • Ward RL; Adult Cancer Program, Lowy Cancer Research Centre, Prince of Wales Clinical School, University of New South Wales, Sydney, NSW, Australia.
  • Chun N; Program for Clinical Cancer Genetics, Departments of Medicine (Oncology) and Genetics, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • Ford JM; Program for Clinical Cancer Genetics, Departments of Medicine (Oncology) and Genetics, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • Ladabaum U; Gastrointestinal Cancer Prevention Program, Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • McKinnon WC; Department of Medicine and Familial Cancer Program, Vermont Cancer Centre, University of Vermont, Burlington, VT, USA.
  • Greenblatt MS; Department of Medicine and Familial Cancer Program, Vermont Cancer Centre, University of Vermont, Burlington, VT, USA.
  • Hitchins MP; 1] Adult Cancer Program, Lowy Cancer Research Centre, Prince of Wales Clinical School, University of New South Wales, Sydney, NSW, Australia [2] Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Eur J Hum Genet ; 22(5): 617-24, 2014 May.
Article em En | MEDLINE | ID: mdl-24084575
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Haplótipos / Proteínas Nucleares / Mutação Puntual / Epigênese Genética / População Branca / Proteínas Adaptadoras de Transdução de Sinal / Genes Dominantes Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Haplótipos / Proteínas Nucleares / Mutação Puntual / Epigênese Genética / População Branca / Proteínas Adaptadoras de Transdução de Sinal / Genes Dominantes Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Ano de publicação: 2014 Tipo de documento: Article