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Generation and characterization of a rabbit monoclonal antibody site-specific for tau O-GlcNAcylated at serine 400.
Cameron, Andrew; Giacomozzi, Brandy; Joyce, John; Gray, Audrey; Graham, Danielle; Ousson, Solenne; Neny, Maud; Beher, Dirk; Carlson, George; O'Moore, Jill; Shearman, Mark; Hering, Heike.
Afiliação
  • Cameron A; EMD Serono Research & Development Institute, Billerica, MA 01821, United States.
FEBS Lett ; 587(22): 3722-8, 2013 Nov 15.
Article em En | MEDLINE | ID: mdl-24113653
Aggregation of tau into paired helical filaments is a pathological process leading to neurotoxicity in Alzheimer's disease and other tauopathies. Tau is posttranslationally modified by O-linked N-acetylglucosamine (O-GlcNAc), and increasing tau O-GlcNAcylation may protect against its aggregation. Research tools to study the relationship between tau aggregation and tau O-GlcNAcylation have not been widely available. Here we describe the generation of a rabbit monoclonal antibody specific for tau O-GlcNAcylated at Ser400 (O-tau(S400)). We show the utility of this antibody for in vitro and in vivo experiments to investigate the function of O-GlcNAc modifications of tau at Ser400.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Processamento de Proteína Pós-Traducional / Proteínas tau / Anticorpos Monoclonais Limite: Animals / Humans Idioma: En Ano de publicação: 2013 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Processamento de Proteína Pós-Traducional / Proteínas tau / Anticorpos Monoclonais Limite: Animals / Humans Idioma: En Ano de publicação: 2013 Tipo de documento: Article