Constitutive mosaic aneuploidy is a unique genetic feature widespread in the Leishmania genus.
Microbes Infect
; 16(1): 61-6, 2014 Jan.
Article
em En
| MEDLINE
| ID: mdl-24120456
ABSTRACT
Using fluorescence in situ hybridization, we determined the ploidy of four species of Leishmania Leishmania infantum, Leishmania donovani, Leishmania tropica and Leishmania amazonensis. We found that each cell in a strain possesses a combination of mono-, di- and trisomies for all chromosomes; ploidy patterns were different among all strains/species. These results extend those we previously described in Leishmania major, demonstrating that mosaic aneuploidy is a genetic feature widespread to the Leishmania genus. In addition to the genetic consequences induced by this mosaicism, the apparent absence of alternation between haploid/diploid stages questions the modality of genetic exchange in Leishmania sp.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aneuploidia
/
Leishmania
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Mosaicismo
Limite:
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article